Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Large conductance, Ca 2+-activated potassium (BK) channels are widely expressed
throughout the animal kingdom and play important roles in many physiological processes …

A homology model of the housefly voltage-gated sodium channel was developed to predict
the location of binding sites for the insecticides fenvalerate, a synthetic pyrethroid, and DDT …

P-glycoprotein (Pgp) is one of the most biomedically relevant transporters in the ATP binding
cassette (ABC) superfamily due to its involvement in develo** multidrug resistance in …

Calcium-activated chloride channels (CaCCs) formed by TMEM16A or TMEM16B are
broadly expressed in the nervous system, smooth muscles, exocrine glands, and other …

Abstract In Arabidopsis (Arabidopsis thaliana), the Shaker K+ channel AKT1 conducts K+
uptake in root cells, and its activity is regulated by CBL1/9-CIPK23 complexes as well as by …

Homozygote varitint-waddler (Va) mice, expressing a mutant isoform (A419P) of TRPML3
(mucolipin 3), are profoundly deaf and display vestibular and pigmentation deficiencies …

We report the crystal structure of the nonselective cation channel NaK from Bacillus cereus
at a resolution of 1.6 Å. The structure reveals the intracellular gate in an open state, as …

Tuned calcium entry through voltage-gated calcium channels is a key requirement for many
cellular functions. This is ensured by channel gates which open during membrane …

hERG potassium channels have a critical role in the normal electrical activity of the heart.
The block of hERG channels can cause the drug-induced form of long QT syndrome, a …