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Regulation and functional roles of chemokines in liver diseases
Inflammation is a major contributor to the pathogenesis of almost all liver diseases. Low-
molecular-weight proteins called chemokines are the main drivers of liver infiltration by …
molecular-weight proteins called chemokines are the main drivers of liver infiltration by …
[HTML][HTML] An overview on single-cell technology for hepatocellular carcinoma diagnosis
Hepatocellular carcinoma is a primary liver cancer caused by the accumulation of genetic
mutation patterns associated with epidemiological conditions. This lethal malignancy …
mutation patterns associated with epidemiological conditions. This lethal malignancy …
Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells
Y Hao, S Song, T Li, Q Zai, N Ma, Y Li… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Background & Aims: Reactive oxygen species (ROS) act as modulators triggering cellular
dysfunctions and organ damage including liver fibrosis in which hepatic stellate cell (HSC) …
dysfunctions and organ damage including liver fibrosis in which hepatic stellate cell (HSC) …
Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells
Z Zhang, X Wang, Z Wang, Z Zhang, Y Cao, Z Wei… - Biofactors, 2021 - Wiley Online Library
Targeting the elimination of activated hepatic stellate cells (HSCs) and blocking excessive
deposition of extracellular matrix are recognized as an effective strategy for the treatment of …
deposition of extracellular matrix are recognized as an effective strategy for the treatment of …
[HTML][HTML] Multiplexed digital spatial protein profiling reveals distinct phenotypes of mononuclear phagocytes in livers with advanced fibrosis
Background and Aims: Intrahepatic mononuclear phagocytes (MPs) are critical for the
initiation and progression of liver fibrosis. In this study, using multiplexed digital spatial …
initiation and progression of liver fibrosis. In this study, using multiplexed digital spatial …
Binding of berberine to PEBP1 synergizes with sorafenib to induce the ferroptosis of hepatic stellate cells
Z **e, Y Zhou, M Lin, C Huang - Amino Acids, 2023 - Springer
Hepatic stellate cell (HSC) activation is the key process in hepatic fibrosis (HF) development.
Targeted death of HSCs could be effective in the prevention and treatment of HF …
Targeted death of HSCs could be effective in the prevention and treatment of HF …
Single-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis
Alcohol-associated hepatitis (AH) is often diagnosed at advanced stages, and severe AH
usually carries poor prognosis and high short-term mortality. In addition, it is challenging to …
usually carries poor prognosis and high short-term mortality. In addition, it is challenging to …
Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis
S Li, QJ Ren, CH **e, Y Cui, LT Xu… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process
in chronic liver injury, and finally leads to liver cirrhosis or even hepatocellular carcinoma …
in chronic liver injury, and finally leads to liver cirrhosis or even hepatocellular carcinoma …
A unique immune-related gene signature represents advanced liver fibrosis and reveals potential therapeutic targets
Innate and adaptive immune responses are critically associated with the progression of
fibrosis in chronic liver diseases. In this study, we aim to identify a unique immune-related …
fibrosis in chronic liver diseases. In this study, we aim to identify a unique immune-related …
[HTML][HTML] Immune Checkpoints and the Immunology of Liver Fibrosis
I Tsomidis, A Voumvouraki, E Kouroumalis - Livers, 2025 - mdpi.com
Liver fibrosis is a very complicated dynamic process where several immune cells are
involved. Both innate and adaptive immunity are implicated, and their interplay is always …
involved. Both innate and adaptive immunity are implicated, and their interplay is always …