Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Abstract Microplastics (MPs;< 5 mm) in the biosphere draws public concern about their
potential health impacts. Humans are potentially exposed to MPs via ingestion, inhalation …

Effective drug delivery and prevention of postoperative recurrence are significant challenges
for current glioblastoma (GBM) treatment. Poor drug delivery is mainly due to the presence …

Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been
approved, but new delivery solutions are needed to target additional organs. Here we show …

The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …

Immunotherapy has had a profound positive effect on certain types of cancer but has not
improved the outcomes of glioma because of the blood–brain barrier (BBB) and …

Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Glioblastoma (GBM) is an aggressive primary brain cancer, with a 5 year survival of∼ 5%.
Challenges that hamper GBM therapeutic efficacy include (i) tumor heterogeneity,(ii) …

Mesoporous silica nanoparticles (MSNs) represent a promising avenue for targeted brain
tumor therapy. However, the blood–brain barrier (BBB) often presents a formidable obstacle …

CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …