Actinomycetes: still a source of novel antibiotics

O Genilloud - Natural product reports, 2017 - pubs.rsc.org
Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …

Micromonospora: A Prolific Source of Bioactive Secondary Metabolites with Therapeutic Potential

S Yan, M Zeng, H Wang, H Zhang - Journal of Medicinal …, 2022 - ACS Publications
Micromonospora, one of the most important actinomycetes genera, is well-known as the
treasure trove of bioactive secondary metabolites (SMs). Herein, together with an in-depth …

A review of the chemistry and biological activities of natural colorants, dyes, and pigments: challenges, and opportunities for food, cosmetics, and pharmaceutical …

A Pasdaran, M Zare, A Hamedi… - Chemistry & …, 2023 - Wiley Online Library
Natural pigments are important sources for the screening of bioactive lead compounds. This
article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from …

Advances in biosynthesis of natural products from marine microorganisms

Q Zhou, K Hotta, Y Deng, R Yuan, S Quan, X Chen - Microorganisms, 2021 - mdpi.com
Natural products play an important role in drug development, among which marine natural
products are an underexplored resource. This review summarizes recent developments in …

[HTML][HTML] Naturalization of treated wastewater by a constructed wetland in a water-scarce Mediterranean region

C Rochera, M Peña, A Picazo, D Morant… - Journal of …, 2024 - Elsevier
The effluents from conventional wastewater treatment plants (WWTP), even if accomplishing
quality regulations, substantially differ in their characteristics with those of waters in natural …

Deciphering Deoxynybomycin Biosynthesis Reveals Fe (II)/α-Ketoglutarate-Dependent Dioxygenase-Catalyzed Oxazoline Ring Formation and Decomposition

K Liu, J Zhang, G Zhang, L Zhang, Z Meng… - Journal of the …, 2023 - ACS Publications
The antibacterial agents deoxynybomycin (DNM) and nybomycin (NM) have a unique
tetracyclic structure featuring an angularly fused 4-oxazoline ring. Here, we report the …

A highly potent class of halogenated phenazine antibacterial and biofilm-eradicating agents accessed through a modular Wohl-Aue synthesis

H Yang, Y Abouelhassan, GM Burch, D Kallifidas… - Scientific Reports, 2017 - nature.com
Unlike individual, free-floating planktonic bacteria, biofilms are surface-attached
communities of slow-or non-replicating bacteria encased within a protective extracellular …

[HTML][HTML] A Pimarane Diterpene and Cytotoxic Angucyclines from a Marine-Derived Micromonospora sp. in Vietnam's East Sea

MW Mullowney, E Ó hAinmhire, U Tanouye… - Marine Drugs, 2015 - mdpi.com
A screening of our actinomycete fraction library against the NCI-60 SKOV3 human tumor cell
line led to the isolation of isopimara-2-one-3-ol-8, 15-diene (1), lagumycin B (2) …

Recent developments in natural product-based drug discovery for tuberculosis

M Dong, B Pfeiffer, KH Altmann - Drug discovery today, 2017 - Elsevier
Highlights•Natural products are at the origin of several TB drugs.•There is a continuous flow
of new natural products with potent anti-Mtb activity.•Modification of older natural products …