Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Complexities of assessing the disease burden attributable to leishmaniasis

C Bern, JH Maguire, J Alvar - PLoS neglected tropical diseases, 2008 - journals.plos.org
Among parasitic diseases, morbidity and mortality caused by leishmaniasis are surpassed
only by malaria and lymphatic filariasis. However, estimation of the leishmaniasis disease …

Diagnosis and treatment of leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical …

N Aronson, BL Herwaldt, M Libman… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that leishmaniasis guidelines cannot always account for individual
variation among patients. They are not intended to supplant physician judgment with respect …

Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance

S Rijal, B Ostyn, S Uranw, K Rai… - Clinical Infectious …, 2013 - academic.oup.com
Abstract Background. Miltefosine (MIL), the only oral drug for visceral leishmaniasis (VL), is
currently the first-line therapy in the VL elimination program of the Indian subcontinent …

Tackling drug resistance and other causes of treatment failure in leishmaniasis

GJ Wijnant, F Dumetz, L Dirkx, D Bulté… - Frontiers in Tropical …, 2022 - frontiersin.org
Leishmaniasis is a tropical infectious disease caused by the protozoan Leishmania parasite.
The disease is transmitted by female sand flies and, depending on the infecting parasite …

Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and …

V Adaui, LF Lye, NS Akopyants, M Zimic… - The Journal of …, 2016 - academic.oup.com
Cutaneous and mucosal leishmaniasis, caused in South America by Leishmania
braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [SbV]) …

New World cutaneous leishmaniasis: updated review of current and future diagnosis and treatment

P Mitropoulos, P Konidas, M Durkin-Konidas - Journal of the American …, 2010 - Elsevier
BACKGROUND: Cutaneous leishmaniasis (CL) has traditionally been underrecognized and
underreported. Improved awareness is warranted as the number of cases has increased as …

Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania (Viannia) …

A Chrusciak-Talhari, R Dietze… - … American journal of …, 2011 - pmc.ncbi.nlm.nih.gov
Miltefosine has been used in the treatment of several new world cutaneous leishmaniasis
(CL) species with variable efficacy. Our study is the first evidence on its clinical efficacy in …

Lipsosomal amphotericin B for treatment of cutaneous leishmaniasis

G Wortmann, M Zapor, R Ressner… - … American journal of …, 2010 - pmc.ncbi.nlm.nih.gov
Treatment options for cutaneous leishmaniasis in the United States are problematic because
the available products are either investigational, toxic, and/or of questionable effectiveness …

Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update

L Reveiz, ANS Maia-Elkhoury, RS Nicholls… - PloS one, 2013 - journals.plos.org
Introduction Leishmaniasis is an important public health problem in the Americas. A
Cochrane review published in 2009 analyzed 38 randomized controlled trials (RCT). We …