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Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis
AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …
Complexities of assessing the disease burden attributable to leishmaniasis
Among parasitic diseases, morbidity and mortality caused by leishmaniasis are surpassed
only by malaria and lymphatic filariasis. However, estimation of the leishmaniasis disease …
only by malaria and lymphatic filariasis. However, estimation of the leishmaniasis disease …
Diagnosis and treatment of leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical …
It is important to realize that leishmaniasis guidelines cannot always account for individual
variation among patients. They are not intended to supplant physician judgment with respect …
variation among patients. They are not intended to supplant physician judgment with respect …
Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance
Abstract Background. Miltefosine (MIL), the only oral drug for visceral leishmaniasis (VL), is
currently the first-line therapy in the VL elimination program of the Indian subcontinent …
currently the first-line therapy in the VL elimination program of the Indian subcontinent …
Tackling drug resistance and other causes of treatment failure in leishmaniasis
Leishmaniasis is a tropical infectious disease caused by the protozoan Leishmania parasite.
The disease is transmitted by female sand flies and, depending on the infecting parasite …
The disease is transmitted by female sand flies and, depending on the infecting parasite …
Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and …
Cutaneous and mucosal leishmaniasis, caused in South America by Leishmania
braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [SbV]) …
braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [SbV]) …
New World cutaneous leishmaniasis: updated review of current and future diagnosis and treatment
P Mitropoulos, P Konidas, M Durkin-Konidas - Journal of the American …, 2010 - Elsevier
BACKGROUND: Cutaneous leishmaniasis (CL) has traditionally been underrecognized and
underreported. Improved awareness is warranted as the number of cases has increased as …
underreported. Improved awareness is warranted as the number of cases has increased as …
Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania (Viannia) …
A Chrusciak-Talhari, R Dietze… - … American journal of …, 2011 - pmc.ncbi.nlm.nih.gov
Miltefosine has been used in the treatment of several new world cutaneous leishmaniasis
(CL) species with variable efficacy. Our study is the first evidence on its clinical efficacy in …
(CL) species with variable efficacy. Our study is the first evidence on its clinical efficacy in …
Lipsosomal amphotericin B for treatment of cutaneous leishmaniasis
G Wortmann, M Zapor, R Ressner… - … American journal of …, 2010 - pmc.ncbi.nlm.nih.gov
Treatment options for cutaneous leishmaniasis in the United States are problematic because
the available products are either investigational, toxic, and/or of questionable effectiveness …
the available products are either investigational, toxic, and/or of questionable effectiveness …
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update
L Reveiz, ANS Maia-Elkhoury, RS Nicholls… - PloS one, 2013 - journals.plos.org
Introduction Leishmaniasis is an important public health problem in the Americas. A
Cochrane review published in 2009 analyzed 38 randomized controlled trials (RCT). We …
Cochrane review published in 2009 analyzed 38 randomized controlled trials (RCT). We …