The mechanical heterogeneity of biomolecular structures is intimately linked to their diverse
biological functions. Applying rigidity theory to biomolecules identifies this heterogeneous …

For deriving maximal advantage from information on biomacromolecular flexibility and
rigidity, results from rigidity analyses must be linked to biologically relevant characteristics of …

The notion of using the evolutionary history encoded within multiple sequence alignments to
predict allosteric mechanisms is appealing. In this approach, correlated mutations are …

Allostery describes the functional coupling between sites in biomolecules. Recently, the role
of changes in protein dynamics for allosteric communication has been highlighted. A …

Understanding the relationship between protein structures and their function is still an open
question that becomes very challenging when allostery plays an important functional role …

Intra-protein information is transmitted over distances via allosteric processes. This
ubiquitous protein process allows for protein function changes due to ligand binding events …

We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance
Constraint Model, which gives a statistical mechanical treatment of network rigidity …

The effects of somatic mutations that transform polyspecific germline (GL) antibodies to
affinity mature (AM) antibodies with monospecificity are compared among three GL-AM Fab …

Redistribution of Flexibility in Stabilizing Antibody Fragment Mutants Follows Le Chatelier's
Principle Page 1 are believed to be contributed by the rotational motion of the side methyl …

Stimulation of E scherichia coli with acetate elevates the acetylation level of the chemotaxis
response regulator CheY. This elevation, in an unknown mechanism, activates CheY to …