Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …

The endocannabinoid system (ECS) is involved in a wide range of biological functions and
comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis …

Despite its essential role in the (patho) physiology of several diseases, CB2R tissue
expression profiles and signaling mechanisms are not yet fully understood. We report the …

The cannabinoid receptor type 1 (CB1R) is pivotal within the endocannabinoid system
regulating various signaling cascades with effects in appetite regulation, pain perception …

Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has
attracted an exponentially growing interest. A key driver for this trend was the ability to image …

The cannabinoid type 2 receptor (CB2) has been implicated in a variety of central and
peripheral inflammatory diseases, prompting significant interest in the development of CB2 …

Despite the broad implications of the cannabinoid type 2 receptor (CB2) in
neuroinflammatory processes, a suitable CB2-targeted probe is currently lacking in clinical …

Amyotrophic Lateral Sclerosis (ALS) is a complex pathology:(i) the neurodegeneration is
chronic and progressive; it starts focally in specific central nervous system (CNS) areas and …

The development of cannabinoid receptor type 2 (CB2R) radioligands for positron emission
tomography (PET) imaging was intensively explored. To overcome the low metabolic …

Selectively targeting the cannabinoid receptor CB2 is an attractive therapeutic strategy for
the treatment of inflammatory pain without psychiatric side effects mediated by the …