Autophagy and autophagy-related pathways in cancer

J Debnath, N Gammoh, KM Ryan - Nature reviews Molecular cell …, 2023 - nature.com
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Autophagy in major human diseases

DJ Klionsky, G Petroni, RK Amaravadi… - The EMBO …, 2021 - embopress.org
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Autophagy in tumour immunity and therapy

H **a, DR Green, W Zou - Nature reviews Cancer, 2021 - nature.com
Autophagy is a regulated mechanism that removes unnecessary or dysfunctional cellular
components and recycles metabolic substrates. In response to stress signals in the tumour …

Autophagy and autophagy-related proteins in cancer

X Li, S He, B Ma - Molecular cancer, 2020 - Springer
Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

The multifaceted role of autophagy in cancer

RC Russell, KL Guan - The EMBO journal, 2022 - embopress.org
Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Targeting autophagy in cancer: recent advances and future directions

RK Amaravadi, AC Kimmelman, J Debnath - Cancer discovery, 2019 - aacrjournals.org
Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

[HTML][HTML] The roles of autophagy in cancer

CW Yun, SH Lee - International journal of molecular sciences, 2018 - mdpi.com
Autophagy is an intracellular degradative process that occurs under several stressful
conditions, including organelle damage, the presence of abnormal proteins, and nutrient …

Autophagy and autophagy-related diseases: a review

T Ichimiya, T Yamakawa, T Hirano… - International journal of …, 2020 - mdpi.com
Autophagy refers to the process involving the decomposition of intracellular components via
lysosomes. Autophagy plays an important role in maintaining and regulating cell …

Targeting autophagy in cancer

AV Onorati, M Dyczynski, R Ojha, RK Amaravadi - Cancer, 2018 - Wiley Online Library
Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular
homeostasis during stress conditions. Dysregulated autophagy has implications in health …

Autophagy and disease: unanswered questions

Y Yang, DJ Klionsky - Cell Death & Differentiation, 2020 - nature.com
Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …