Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …

Transposable elements are abundant in the human genome, and great strides have been
made in pinpointing variations in these repetitive sequences using whole-genome …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

Chromatin accessibility and modification is a hallmark of regulatory DNA, the study of which
led to the discovery of cis-regulatory elements (CREs). Here, we characterize chromatin …

In mammals, early resistance to viruses relies on interferons, which protect differentiated
cells but not stem cells from viral replication. Many other organisms rely instead on RNA …

MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by
Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating …

Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …