The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-
autonomous program but as a multifaceted and complex series of events, which is …

Intravital microscopy (IVM) is a powerful technique that enables imaging of internal tissues at
(sub) cellular resolutions in living animals. Here, we present a silicone-based imaging …

Genetically encoded Förster resonance energy transfer (FRET)-based biosensors have
been developed for the visualization of signaling molecule activities. Currently, most of them …

Tissues are heterogeneous with respect to cellular and non-cellular components and in the
dynamic interactions between these elements. To study the behaviour and fate of individual …

The dense desmoplastic and fibrotic stroma is a characteristic feature of pancreatic ductal
adenocarcinoma (PDAC), regulating disease progression, metastasis and response to …

Intravital microscopy can provide unique insights into the function of biological processes in
a native context. However, physiological motion caused by peristalsis, respiration and the …

Imaging subcellular processes in live animals is no longer a dream. The development of
Intravital Subcellular Microscopy (ISMic) combined with the astounding repertoire of …

Breast cancer is a pathological condition characterized by high morphological and
molecular heterogeneity. Not only the breast cancer cells, but also their tumor micro …

Aberrant AKT activation occurs in a number of cancers, metabolic syndrome, and immune
disorders, making it an important target for the treatment of many diseases. To monitor …