Adenosine A2A antagonists can exert antiparkinsonian effects in animal models. Recent
experiments studied the ability of MSX-3 (an adenosine A2A antagonist) to reverse the …

Tremor is a cardinal symptom of parkinsonism, occurring early on in the disease course and
affecting more than 70% of patients. Parkinsonian resting tremor occurs in a frequency …

Long-term therapy with l-3, 4-dihydroxyphenylalanine (l-DOPA), still the most effective
treatment in Parkinson's disease (PD), is associated with severe motor complications such …

AIMS: The aim of the present study is to evaluate the effects of baicalein on the 6-
hydroxydopamine (6-OHDA)-induced rat model of Parkinsonian tremor and elucidate the …

Introduction: Tardive dyskinesia is a serious motor disorder of the orofacial region, resulting
from chronic neuroleptic treatment of schizophrenia. Candesartan (AT1 antagonist) and …

Rationale Nonselective muscarinic acetylcholine antagonists have been used for several
years as antiparkinsonian drugs. However, there are at least five subtypes of muscarinic …

Adenosine A1 and A2A receptors are colocalized with dopamine D1 and D2 receptors on
striatal projection neurons and adenosine antagonists have been proposed as adjunctive …

The spectrum of involuntary movements seen in essential tremor (ET) is limited. Jaw tremor
is one such movement. The prevalence and clinical correlates of jaw tremor have not been …

Typical antipsychotic drugs, including haloperidol and pimozide, have been shown to
produce parkinsonian motor effects such as akinesia and tremor. Furthermore, there is an …

Dopamine D2 and adenosine A2A receptors interact to regulate aspects of motor and
motivational function, and it has been suggested that adenosine A2A antagonists could be …