Exploring the journey: a comprehensive review of vaccine development against Klebsiella pneumoniae

B Douradinha - Microbiological Research, 2024 - Elsevier
Klebsiella pneumoniae, a prominent nosocomial pathogen, poses a critical global health
threat due to its multidrug-resistant (MDR) and hypervirulent strains. This comprehensive …

Computational strategies in Klebsiella pneumoniae vaccine design: navigating the landscape of in silico insights.

B Douradinha - Biotechnology Advances, 2024 - Elsevier
The emergence of multidrug-resistant Klebsiella pneumoniae poses a grave threat to global
public health, necessitating urgent strategies for vaccine development. In this context …

Vaccinomics-based next-generation multi-epitope chimeric vaccine models prediction against Leishmania tropica - a hierarchical subtractive proteomics and …

S Aiman, A Ahmad, AA Khan, AM Alanazi… - Frontiers in …, 2023 - frontiersin.org
Leishmania tropica is a vector-borne parasitic protozoa that is the leading cause of
leishmaniasis throughout the global tropics and subtropics. L. tropica is a multidrug-resistant …

Rational design of novel peptide-based vaccine against the emerging OZ virus

F Arshad, A Sarfraz, A Rubab, M Shehroz, AA Moura… - Human Immunology, 2024 - Elsevier
Oz virus (OZV) belongs to the Orthomyxoviridae family which includes viruses with a
negative-sense, single-stranded, and segmented RNA genome. OZV is a zoonotic …

Core-genome guided novel therapeutic targets identification and chimeric vaccine designing against Rickettsia rickettsii

F Arshad, A Sarfraz, M Shehroz, U Nishan… - Scientific Reports, 2025 - nature.com
Abstract Rocky Mountain Spotted Fever, caused by the gram-negative intracellular bacteria
Rickettsia rickettsii, is a serious tick-borne infection with a fatality rate of 20–30%, if not …

Targeting MurG enzyme in Klebsiella pneumoniae: An in silico approach to novel antimicrobial discovery

P Mahur, AK Singh, J Muthukumaran, M Jain - Research in Microbiology, 2025 - Elsevier
Antibiotic resistance poses a global crisis fuelled by widespread antibiotic use, particularly
against Gram-negative bacteria like Klebsiella pneumoniae, a leading cause of hospital …

In silico design and assessment of a multi-epitope peptide vaccine against multidrug-resistant Acinetobacter baumannii

SN Sah, S Gupta, N Bhardwaj, LK Gautam… - In Silico …, 2024 - Springer
Acinetobacter baumannii, an opportunistic and notorious nosocomial pathogen, is
responsible for many infections affecting soft tissues, skin, lungs, bloodstream, and urinary …

Computer-aided rational design of a mRNA vaccine against Guanarito mammarenavirus

M Shah, A Sarfraz, M Shehroz, A Perveen, S Jaan… - Biotechnology …, 2025 - Springer
Purpose Guanarito mammarenavirus (GTOV) is a highly pathogenic virus that leads to
Venezuelan hemorrhagic fever (VHF). Despite being a severe disease, there are currently …

[HTML][HTML] Exploring Ventilator-Associated Pneumonia: Microbial Clues and Biomarker Insights from a Retrospective Study

AM Gouda, AE Sileem, HM Elnahas, AE Tawfik, RA Eid… - Medicina, 2024 - mdpi.com
Background and Objectives: Ventilator-associated pneumonia (VAP) is a common
complication in critically ill patients receiving mechanical ventilation. The incidence rates of …

Application of Reverse Vaccinology and Immunoinformatics to Design a Multitope Vaccine Against Gastrointestinal Cancer-Inducing Cryptosporidium Parvum

MA Soltan, WK Abdulsahib, RA Eid… - Journal of …, 2025 - ui.adsabs.harvard.edu
Cryptosporidium parvum (C. parvum) is an apicomplexan protozoan known as a frequent
cause of diarrhea. Because of its severe outbreaks and the association with different types of …