• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The wide spread of antibiotic resistance has been alarming in recent years and poses a
serious global hazard to public health as it leads to millions of deaths all over the world. The …

Staphylococcus aureus is a microorganism frequently associated with implant-related
infections, owing to its ability to produce biofilms. These infections are difficult to treat …

Resistance to antimicrobial agents has been alarming in recent years and poses a huge
public health threat globally according to the WHO. The increase in morbidity and mortality …

Microorganisms grouped together into spatially-organized communities called biofilms, are
the cause of dramatic chronic infections in plants, animals and humans. In this review, the …

Bacterial biofilms are highly recalcitrant to antibiotic therapies due to multiple tolerance
mechanisms. The involvement of Pseudomonas aeruginosa in a wide range of biofilm …

Prosthetic joint infection (PJI) is a severe complication after arthroplasty. Its management
combines surgical intervention, whose type depends on the clinical situation, and prolonged …

For four decades, physicians and other healthcare providers have trusted Mandell, Douglas,
and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on …

Over half of the nearly two million healthcare-associated infections can be attributed to
indwelling medical devices. In this review, we highlight the difficulty in diagnosing …

Natural products have historically been a rich source of diverse chemical matter with
numerous biological activities, and have played an important role in drug discovery in many …