Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …

Taxane‐derived drugs are antineoplastic agents used for the treatment of highly common
malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however …

Background Neuropathic pain is a clinically relevant adverse effect of several anticancer
drugs that markedly impairs patients' quality of life and frequently leads to dose reduction or …

Painful peripheral neuropathy is a common side effect of paclitaxel (PTX). The use of
analgesics is an important component for management of PTX-induced peripheral …

Cancer represents one of the most pernicious public health problems with a high mortality
rate among patients worldwide. Chemotherapy is one of the major therapeutic approaches …

Endothelial mesenchymal transition (EndMT) has been described as a fundamental process
during embryogenesis; however, it can occur also in adult age, underlying pathological …

The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with
various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The …

The design of dualsteric/bitopic agents as single chemical entities able to simultaneously
interact with both the orthosteric and an allosteric binding site represents a novel approach …

Significance: Hydrogen sulfide (H2S), the “new entry” in the series of endogenous
gasotransmitters, plays a fundamental role in regulating the biological functions of various …