Changes in lean body mass with glucagon‐like peptide‐1‐based therapies and mitigation strategies

IJ Neeland, J Linge… - Diabetes, Obesity and …, 2024 - Wiley Online Library
Weight loss induced by glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and dual
glucagon‐like peptide‐1 receptor (GLP‐1R)/glucose‐dependent insulinotropic polypeptide …

Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity

JI Mechanick, WS Butsch, SM Christensen… - Obesity …, 2025 - Wiley Online Library
The rapid and widespread clinical adoption of highly effective incretin‐mimetic drugs (IMDs),
particularly semaglutide and tirzepatide, for the treatment of obesity has outpaced the …

Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle …

R Sandireddy, S Sakthivel, P Gupta, J Behari… - Frontiers in cell and …, 2024 - frontiersin.org
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-
alcoholic fatty liver disease (NAFLD), is the most common liver disorder worldwide, with an …

Core components of cardiac rehabilitation programs: 2024 update: a scientific statement from the American Heart Association and the American Association of …

TM Brown, QR Pack, E Aberegg, LPC Brewer… - Circulation, 2024 - ahajournals.org
The science of cardiac rehabilitation and the secondary prevention of cardiovascular
disease has progressed substantially since the most recent American Heart Association and …

Management of coronary artery disease in older adults: recent advances and gaps in evidence

S Cacciatore, L Spadafora, M Bernardi, M Galli… - Journal of clinical …, 2023 - mdpi.com
Coronary artery disease (CAD) is highly prevalent in older adults, yet its management
remains challenging. Treatment choices are made complex by the frailty burden of older …

[HTML][HTML] Vascular impairment, muscle atrophy, and cognitive decline: Critical age-related conditions

EP de Lima, M Tanaka, CB Lamas, K Quesada… - Biomedicines, 2024 - mdpi.com
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical
age-related conditions that significantly impact health. Vascular impairment disrupts blood …

Genetic association and potential mediators between sarcopenia and coronary heart disease: A bidirectional two-sample, two-step mendelian randomization study

J He, M Huang, N Li, L Zha, J Yuan - Nutrients, 2023 - mdpi.com
Objective: To elucidate the bidirectional correlation of sarcopenia with coronary heart
disease (CHD), as well as to investigate the mediating role of cardiometabolic factors and …

Muscle mass and glucagon-like peptide-1 receptor agonists: adaptive or maladaptive response to weight loss?

J Linge, AL Birkenfeld, IJ Neeland - Circulation, 2024 - ahajournals.org
Recent studies have shown that pharmacologic weight loss with glucagon-like peptide-1
receptor agonists (GLP-1 RAs) and combination therapies is approaching magnitudes …

Effects of exercise on circadian rhythms in humans

B Shen, C Ma, G Wu, H Liu, L Chen… - Frontiers in …, 2023 - frontiersin.org
The biological clock system is an intrinsic timekee** device that integrates internal
physiology and external cues. Maintaining a healthy biological clock system is crucial for life …

Relationship between sarcopenia and intensive blood pressure control efficacy and safety: a secondary analysis of SPRINT

S Mirzai, I Persits, R Kazibwe, M Gabani, A Seals… - …, 2024 - ahajournals.org
BACKGROUND: Sarcopenia and hypertension are independently associated with worse
cardiovascular disease (CVD) risk and survival. While individuals with sarcopenia may …