▪ Abstract The conversion of exogenous and endogenous proteins into immunogenic
peptides recognized by T lymphocytes involves a series of proteolytic and other enzymatic …

The purpose of this article is to provide a compendium of major histocompatibility complex
(MHC) peptide motifs and MHC ligands known to date, together with a discussion of the …

Peptide antigens bound to molecules encoded by the major histocompatibility complex
(MHC) and presented on the cell surface form the targets of T lymphocytes. This critical arm …

ACHONDROPLASIA, the most common cause of chondrodysplasia in man (1 in 15,000 live
births), is a condition of unknown origin characterized by short-limbed dwarfism and …

Increased synthesis of heat shock proteins (hsp) occurs in prokaryotic and eukaryotic cells
when they are exposed to stress. By increasing their hsp content, cells protect themselves …

Specificity and Promiscuity among Naturally Processed Peptides Bound to HLA-DR Alleles
By Roman M. Chicz, Robert G. Urban, Joan Page 1 Specificity and Promiscuity among …

Recent developments have led to a clearer understanding of the association between
peptides and MHC molecules. It is now clear that the peptides presented by MHC class I or …

TCR downmodulation following ligation by MHC: peptide complexes is considered to be a
pivotal event in T cell activation. Here, we analyzed the dynamics of TCR: CD3 cell surface …

We have approached the problem of MHC class II ligand motifs by pool sequencing natural
peptides eluted from HLA-DR, DQ, and DP molecules. The results indicate surprisingly clear …

The HLA complex in Goodpasture's disease: A model for analyzing susceptibility to
autoimmunity. Human lymphocyte antigen (HLA) associations are recognized for many …