Antimicrobial peptides: an update on classifications and databases

A Bin Hafeez, X Jiang, PJ Bergen, Y Zhu - International journal of …, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

The microbiome-sha** roles of bacteriocins

S Heilbronner, B Krismer, H Brötz-Oesterhelt… - Nature Reviews …, 2021 - nature.com
The microbiomes on human body surfaces affect health in multiple ways. They include not
only commensal or mutualistic bacteria but also potentially pathogenic bacteria, which can …

Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations

S Soltani, R Hammami, PD Cotter… - FEMS microbiology …, 2021 - academic.oup.com
In recent decades, bacteriocins have received substantial attention as antimicrobial
compounds. Although bacteriocins have been predominantly exploited as food …

[HTML][HTML] Biosynthetic potential of the global ocean microbiome

L Paoli, HJ Ruscheweyh, CC Forneris, F Hubrich… - Nature, 2022 - nature.com
Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …

Antimicrobial peptide synergies for fighting infectious diseases

JT Mhlongo, AY Waddad, F Albericio… - Advanced …, 2023 - Wiley Online Library
Antimicrobial peptides (AMPs) are essential elements of thehost defense system.
Characterized by heterogenous structures and broad‐spectrumaction, they are promising …

Mining genomes to illuminate the specialized chemistry of life

MH Medema, T de Rond, BS Moore - Nature Reviews Genetics, 2021 - nature.com
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Adding α, α-disubstituted and β-linked monomers to the genetic code of an organism

DL Dunkelmann, C Piedrafita, A Dickson, KC Liu… - Nature, 2024 - nature.com
The genetic code of living cells has been reprogrammed to enable the site-specific
incorporation of hundreds of non-canonical amino acids into proteins, and the encoded …