L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Cell–cell communication, which enables cells to coordinate their activity and is essential for
growth, development and function, is usually ascribed a chemical or electrical origin …

Heart failure is a leading cause of death in humans, and stress is increasingly associated
with adverse cardiac outcomes. Glucocorticoids are primary stress hormones, but their direct …

Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in
humans and animal models, but effective neuronal hyperactivity-directed anti-AD …

Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α
(RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including …

Physiological processes governing the heart beat have been under investigation for several
hundred years. Major advances have been made in the recent past. A review of the present …

Ca 2+ fluxes between adjacent organelles are thought to control many cellular processes,
including metabolism and cell survival. In vitro evidence has been presented that …

Arrhythmogenic cardiomyopathy has been clinically defined since the 1980s and causes
right or biventricular cardiomyopathy associated with ventricular arrhythmia. Although it is a …

Background: The human genome folds in 3 dimensions to form thousands of chromatin
loops inside the nucleus, encasing genes and cis-regulatory elements for accurate gene …