Brain metastases (BMs) are the most common intracranial tumor type and a significant
health concern, affecting approximately 10% to 30% of all oncological patients. Although …

Mathematical oncology provides unique and invaluable insights into tumour growth on both
the microscopic and macroscopic levels. This review presents state-of-the-art modelling …

We study the effect of intra-tumor heterogeneity on the dynamics of a growing tumor, utilizing
a two-dimensional continuum model. The cancerous phase is divided into two sub-phases …

Metastasis is the process through which cancer cells break away from a primary tumor,
travel through the blood or lymph system, and form new tumors in distant tissues. One of the …

Tumor growth is the result of the interplay of complex biological processes in huge numbers
of individual cells living in changing environments. Effective simple mathematical laws have …

Computational models of tumor growth are valuable for simulating the dynamics of cancer
progression and treatment responses. In particular, agent-based models (ABMs) tracking …

In vivo observations show that oxygen levels in tumours can fluctuate on fast and slow
timescales. As a result, cancer cells can be periodically exposed to pathologically low …

Background Temozolomide (TMZ) is an oral alkylating agent active against gliomas with a
favorable toxicity profile. It is part of the standard of care in the management of glioblastoma …

Osteoarthritis (OA) is a multifaceted degenerative joint disorder affected by various risk
factors such as age, mechanical stress, inflammation, and metabolic influences. These …

Microscale oxygenation plays a prominent role in tumour progression. Spatiotemporal
variability of oxygen distribution in the tumour microenvironment contributes to cellular …