Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been …

Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …

The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …

During recent years, the preclinical stage of Alzheimer's disease (AD) has become a major
focus of research. Continued failures in clinical trials and the realization that early …

Fast synaptic communication in the brain requires synchronous vesicle fusion that is evoked
by action potential-induced Ca2+ influx. However, synaptic terminals also release …

Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine,
an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces …

Neural circuits must maintain stable function in the face of many plastic challenges,
including changes in synapse number and strength, during learning and development …

Ketamine exerts rapid antidepressant action in depressed and treatment-resistant
depressed patients within hours. At the same time, ketamine elicits a unique form of …

Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptic physiology, as well
as mechanisms underlying various neuropsychiatric diseases and their treatment. Despite …