Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy

C Campbell, MR Kandalgaonkar, RM Golonka… - Biomedicines, 2023 - mdpi.com
Gut microbes and their metabolites are actively involved in the development and regulation
of host immunity, which can influence disease susceptibility. Herein, we review the most …

The gut microbiome: Relationships with disease and opportunities for therapy

J Durack, SV Lynch - Journal of experimental medicine, 2019 - rupress.org
Introduction to the field of microbiome research Over evolutionary time, humans have
developed symbiotically with a diversity of environmental microbial species (Sender et al …

Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

LM Sanmarco, MA Wheeler, C Gutiérrez-Vázquez… - Nature, 2021 - nature.com
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …

The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies

L Zitvogel, Y Ma, D Raoult, G Kroemer, TF Gajewski - Science, 2018 - science.org
The fine line between human health and disease can be driven by the interplay between
host and microbial factors. This “metagenome” regulates cancer initiation, progression, and …

Prevotella copri in individuals at risk for rheumatoid arthritis

D Alpizar-Rodriguez, TR Lesker, A Gronow… - Annals of the …, 2019 - ard.bmj.com
Objectives Rheumatoid arthritis (RA) has been associated with a relative expansion of
faecal Prevotellaceae. To determine the microbiome composition and prevalence of …

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

S Lucas, Y Omata, J Hofmann, M Böttcher… - Nature …, 2018 - nature.com
Microbial metabolites are known to modulate immune responses of the host. The main
metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain …

Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms

L Osbelt, ÉH Almási, M Wende, S Kienesberger… - Nature …, 2024 - nature.com
The Klebsiella oxytoca species complex is part of the human microbiome, especially during
infancy and childhood. K. oxytoca species complex strains can produce enterotoxins …

E. coli enhance colonization resistance against Salmonella Typhimurium by competing for galactitol, a context-dependent limiting carbon source

C Eberl, AS Weiss, LM Jochum, ACD Raj, D Ring… - Cell Host & Microbe, 2021 - cell.com
The composition of intrinsic microbial communities determines if invading pathogens will
find a suitable niche for colonization and cause infection or be eliminated. Here, we …

Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa

P Pandiyan, N Bhaskaran, M Zou, E Schneider… - Frontiers in …, 2019 - frontiersin.org
Mammals co-exist with resident microbial ecosystem that is composed of an incredible
number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident …

Functional immune cell–astrocyte interactions

LM Sanmarco, CM Polonio, MA Wheeler… - Journal of Experimental …, 2021 - rupress.org
Astrocytes are abundant glial cells in the central nervous system (CNS) that control multiple
aspects of health and disease. Through their interactions with components of the blood …