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Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy
Gut microbes and their metabolites are actively involved in the development and regulation
of host immunity, which can influence disease susceptibility. Herein, we review the most …
of host immunity, which can influence disease susceptibility. Herein, we review the most …
The gut microbiome: Relationships with disease and opportunities for therapy
Introduction to the field of microbiome research Over evolutionary time, humans have
developed symbiotically with a diversity of environmental microbial species (Sender et al …
developed symbiotically with a diversity of environmental microbial species (Sender et al …
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …
have important homeostatic and disease-promoting functions. However, little is known about …
The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies
The fine line between human health and disease can be driven by the interplay between
host and microbial factors. This “metagenome” regulates cancer initiation, progression, and …
host and microbial factors. This “metagenome” regulates cancer initiation, progression, and …
Prevotella copri in individuals at risk for rheumatoid arthritis
D Alpizar-Rodriguez, TR Lesker, A Gronow… - Annals of the …, 2019 - ard.bmj.com
Objectives Rheumatoid arthritis (RA) has been associated with a relative expansion of
faecal Prevotellaceae. To determine the microbiome composition and prevalence of …
faecal Prevotellaceae. To determine the microbiome composition and prevalence of …
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
Microbial metabolites are known to modulate immune responses of the host. The main
metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain …
metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain …
Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms
The Klebsiella oxytoca species complex is part of the human microbiome, especially during
infancy and childhood. K. oxytoca species complex strains can produce enterotoxins …
infancy and childhood. K. oxytoca species complex strains can produce enterotoxins …
E. coli enhance colonization resistance against Salmonella Typhimurium by competing for galactitol, a context-dependent limiting carbon source
The composition of intrinsic microbial communities determines if invading pathogens will
find a suitable niche for colonization and cause infection or be eliminated. Here, we …
find a suitable niche for colonization and cause infection or be eliminated. Here, we …
Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa
P Pandiyan, N Bhaskaran, M Zou, E Schneider… - Frontiers in …, 2019 - frontiersin.org
Mammals co-exist with resident microbial ecosystem that is composed of an incredible
number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident …
number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident …
Functional immune cell–astrocyte interactions
Astrocytes are abundant glial cells in the central nervous system (CNS) that control multiple
aspects of health and disease. Through their interactions with components of the blood …
aspects of health and disease. Through their interactions with components of the blood …