Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to …

JG Chase, JC Preiser, JL Dickson, A Pironet… - Biomedical engineering …, 2018 - Springer
Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Digital twins and automation of care in the intensive care unit

J Geoffrey Chase, C Zhou, JL Knopp… - Cyber–Physical …, 2023 - Wiley Online Library
Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …

Continuous glucose monitoring in neonates: a review

CJD McKinlay, JG Chase, J Dickson, DL Harris… - … health, neonatology and …, 2017 - Springer
Continuous glucose monitoring (CGM) is well established in the management of diabetes
mellitus, but its role in neonatal glycaemic control is less clear. CGM has provided important …

Continuous glucose monitoring in transient neonatal diabetes mellitus—2 case reports and literature review

T Chisnoiu, AL Balasa, L Mihai, A Lupu, CE Frecus… - Diagnostics, 2023 - mdpi.com
Neonatal diabetes mellitus is a rare genetic disease that affects 1 in 90,000 live births. The
start of the disease is often before the baby is 6 months old, with rare cases of onset …

Glycemic control in the intensive care unit: a control systems perspective

JG Chase, B Benyo, T Desaive - Annual Reviews in Control, 2019 - Elsevier
Computers and automation have revolutionised quality and productivity in many industries,
but not in medicine. Healthcare costs are thus growing beyond the ability of society to pay for …

Outcomes of very preterm infants with hyperglycaemia treated with insulin: a systematic review and meta‐analysis

N Patidar, CP Rath, S Rao, S Patole - Acta Paediatrica, 2023 - Wiley Online Library
Aim To study the outcomes of very preterm infants with hyperglycaemia treated with Insulin.
Methods This is a systematic review of randomised controlled trials (RCTs) and …

[HTML][HTML] Classification-based deep neural network vs mixture density network models for insulin sensitivity prediction problem

B Benyó, B Paláncz, Á Szlávecz, B Szabó… - Computer Methods and …, 2023 - Elsevier
Abstract Model-based glycemic control (GC) protocols are used to treat stress-induced
hyperglycaemia in intensive care units (ICUs). The STAR (Stochastic-TARgeted) glycemic …

Current trends and future challenges in neonatal parenteral nutrition

DH Adamkin, PG Radmacher - Journal of neonatal-perinatal …, 2014 - content.iospress.com
A number of adaptations in total parenteral nutrition (TPN) protocols and practices for
preterm neonates have been realized in the past several years, resulting in better survival …

[HTML][HTML] Model-based subcutaneous insulin for glycemic control of pre-term infants in the neonatal intensive care unit

T Zhou, M Boettger, JL Knopp, M Lange, A Heep… - Computers in Biology …, 2023 - Elsevier
Hyperglycaemia is a common problem in neonatal intensive care units (NICUs). Achieving
good control can result in better outcomes for patients. However, good control is difficult …

The potential risks and benefits of insulin treatment in hyperglycaemic preterm neonates

C Morgan - Early Human Development, 2015 - Elsevier
Preterm hyperglycaemia in the first 2 weeks of life is common under 29 weeks gestation and
is associated with increased mortality and morbidity. While the definition of hyperglycaemia …