Functional connectivity in in vitro neuronal assemblies

D Poli, VP Pastore, P Massobrio - Frontiers in neural circuits, 2015 - frontiersin.org
Complex network topologies represent the necessary substrate to support complex brain
functions. In this work, we reviewed in vitro neuronal networks coupled to Micro-Electrode …

Self-organization and neuronal avalanches in networks of dissociated cortical neurons

V Pasquale, P Massobrio, LL Bologna, M Chiappalone… - Neuroscience, 2008 - Elsevier
Dissociated cortical neurons from rat embryos cultured onto micro-electrode arrays exhibit
characteristic patterns of electrophysiological activity, ranging from isolated spikes in the first …

Dissociated cortical networks show spontaneously correlated activity patterns during in vitro development

M Chiappalone, M Bove, A Vato, M Tedesco… - Brain research, 2006 - Elsevier
In vitro cultured neuronal networks coupled to microelectrode arrays (MEAs) constitute a
valuable experimental model for studying changes in the neuronal dynamics at different …

Active pixel sensor array for high spatio-temporal resolution electrophysiological recordings from single cell to large scale neuronal networks

L Berdondini, K Imfeld, A Maccione, M Tedesco… - Lab on a Chip, 2009 - pubs.rsc.org
This paper presents a chip-based electrophysiological platform enabling the study of micro-
and macro-circuitry in in-vitro neuronal preparations. The approach is based on a 64× 64 …

Coupling resistive switching devices with neurons: state of the art and perspectives

A Chiolerio, M Chiappalone, P Ariano… - Frontiers in …, 2017 - frontiersin.org
Here we provide the state-of-the-art of bioelectronic interfacing between biological neuronal
systems and artificial components, focusing the attention on the potentiality offered by …

Network dynamics of 3D engineered neuronal cultures: a new experimental model for in-vitro electrophysiology

M Frega, M Tedesco, P Massobrio, M Pesce… - Scientific reports, 2014 - nature.com
Despite the extensive use of in-vitro models for neuroscientific investigations and
notwithstanding the growing field of network electrophysiology, all studies on cultured cells …

On the dynamics of the spontaneous activity in neuronal networks

A Mazzoni, FD Broccard, E Garcia-Perez, P Bonifazi… - PloS one, 2007 - journals.plos.org
Most neuronal networks, even in the absence of external stimuli, produce spontaneous
bursts of spikes separated by periods of reduced activity. The origin and functional role of …

Network dynamics and synchronous activity in cultured cortical neurons

M Chiappalone, A Vato, L Berdondini… - … journal of neural …, 2007 - World Scientific
Neurons extracted from specific areas of the Central Nervous System (CNS), such as the
hippocampus, the cortex and the spinal cord, can be cultured in vitro and coupled with a …

Identification of excitatory-inhibitory links and network topology in large-scale neuronal assemblies from multi-electrode recordings

VP Pastore, P Massobrio, A Godjoski… - PLoS computational …, 2018 - journals.plos.org
Functional-effective connectivity and network topology are nowadays key issues for studying
brain physiological functions and pathologies. Inferring neuronal connectivity from …

Emergent functional properties of neuronal networks with controlled topology

E Marconi, T Nieus, A Maccione, P Valente, A Simi… - PloS one, 2012 - journals.plos.org
The interplay between anatomical connectivity and dynamics in neural networks plays a key
role in the functional properties of the brain and in the associated connectivity changes …