Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

COVID-19 impacts on child and youth anxiety and depression: challenges and opportunities

D Courtney, P Watson, M Battaglia… - The Canadian …, 2020 - journals.sagepub.com
As a result of the COVID-19 pandemic, disaster psychiatry is becoming a core component of
work for mental health professionals around the world. It requires a new flexibility in how we …

Childhood adversity and neural development: A systematic review

KA McLaughlin, D Weissman… - Annual review of …, 2019 - annualreviews.org
An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …

Early adversity and critical periods: neurodevelopmental consequences of violating the expectable environment

CA Nelson, LJ Gabard-Durnam - Trends in neurosciences, 2020 - cell.com
It is now widely recognized that children exposed to adverse life events in the first years of
life are at increased risk for a variety of neural, behavioral, and psychological sequelae. As …

Rethinking concepts and categories for understanding the neurodevelopmental effects of childhood adversity

KE Smith, SD Pollak - Perspectives on psychological science, 2021 - journals.sagepub.com
Discovering the processes through which early adverse experiences affect children's
nervous-system development, health, and behavior is critically important for develo** …

A shifting role of thalamocortical connectivity in the emergence of cortical functional organization

S Park, KV Haak, S Oldham, H Cho, K Byeon… - Nature …, 2024 - nature.com
The cortical patterning principle has been a long-standing question in neuroscience, yet
how this translates to macroscale functional specialization in the human brain remains …

Hidden talents in harsh environments

BJ Ellis, LS Abrams, AS Masten… - Development and …, 2022 - cambridge.org
Although early-life adversity can undermine healthy development, children growing up in
harsh environments may develop intact, or even enhanced, skills for solving problems in …

Advocacy for improving nutrition in the first 1000 days to support childhood development and adult health

SJ Schwarzenberg, MK Georgieff, S Daniels… - …, 2018 - publications.aap.org
Advocacy for Improving Nutrition in the First 1000 Days to Support Childhood Development
and Adult Health | Pediatrics | American Academy of Pediatrics Skip to Main Content …

Biological embedding of childhood adversity: from physiological mechanisms to clinical implications

AE Berens, SKG Jensen, CA Nelson - BMC medicine, 2017 - Springer
Background Adverse psychosocial exposures in early life, namely experiences such as child
maltreatment, caregiver stress or depression, and domestic or community violence, have …

Systematic review of pediatric health outcomes associated with childhood adversity

DL Oh, P Jerman, S Silvério Marques, K Koita… - BMC pediatrics, 2018 - Springer
Background Early detection of and intervention in childhood adversity has powerful potential
to improve the health and well-being of children. A systematic review was conducted to …