The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Tumours are known as wounds that do not heal—this implies that cells that are involved in
angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a …

There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Cardiovascular disease is a leading cause of death worldwide and there is a pressing need
for new therapeutic strategies to treat such conditions. The risk of develo** cardiovascular …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

The importance of fibrosis in organ pathology and dysfunction appears to be increasingly
relevant to a variety of distinct diseases. In particular, a number of different cardiac …

Cardiovascular disease (CVD) remains a worldwide public health concern despite decades
of research and the availability of numerous targeted therapies. While the intrinsic …

Abstract Cancer-associated fibroblasts (CAFs), are the key effector cells in pancreatic ductal
adenocarcinoma (PDAC), known to induce tumor growth and progression. Pancreatic …