Cryptosporidium is a protozoan parasite of medical and veterinary importance that causes
gastroenteritis in a variety of vertebrate hosts. Several studies have reported different …

Calcium controls many critical events in the complex life cycles of apicomplexan parasites
including protein secretion, motility, and development. Calcium levels are normally tightly …

Examining host–pathogen interactions in animals can capture aspects of infection that are
obscured in cell culture. Using CRISPR-based screens, we functionally profile the entire …

Cryptosporidium are parasitic protozoans that cause gastrointestinal disease and represent
a significant risk to public health. Cryptosporidium oocysts are prevalent in surface waters as …

Plasmodium parasites are fertilized in the mosquito midgut and develop into motile zygotes,
called ookinetes, which invade the midgut epithelium. Here we show that a calcium …

The parasite Cryptosporidium invades and replicates in intestinal epithelial cells and is a
leading cause of diarrheal disease and early childhood mortality. The molecular …

The phylum Apicomplexa comprises a large group of early branching eukaryotes that
includes a number of human and animal parasites. Calcium controls a number of vital …

The protozoans Cryptosporidium parvum and Toxoplasma gondii are parasites of major
health concern to humans. Both parasites contain a group of calcium-dependent protein …

Intracellular pathogens such as viruses and bacteria subvert all the major cellular functions
of their hosts. Targeted host processes include protein synthesis, membrane trafficking …

A key process in the lifecycle of the malaria parasite Plasmodium falciparum is the fast
invasion of human erythrocytes. Entry into the host cell requires the apical membrane …