Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

The development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer
treatment, enabling the possibility of long-term survival in patients with metastatic disease …

Recent years have seen an outstanding growth in the understanding of connections
between diet-induced obesity, dysbiosis and alterations in the tumor microenvironment. Now …

Immunotherapy shows great promise in the treatment of hepatocellular carcinoma (HCC),
however, the low response rate of HCC patients to immunotherapy caused by inadequately …

Simple Summary Triple-negative breast cancer (TNBC) is a highly aggressive tumor with a
poor prognosis and limited treatment options. Finding new approaches to improve TNBC …

Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …

Background Cancer-associated cachexia is a multi-organ disorder associated with
progressive weight loss due to a variable combination of anorexia, systemic inflammation …

Obesity is a complex metabolic condition considered a worldwide public health crisis, and a
deeper mechanistic understanding of obesity-associated diseases is urgently needed …

Obesity is associated with an increased risk for 13 different cancers. The increased risk for
cancer in obesity is mediated by obesity-associated changes in the immune system. Obesity …

Expression of immune checkpoint proteins restrict immunosurveillance in the tumor
microenvironment; thus, FDA-approved checkpoint inhibitor drugs, specifically PD-1/PD-L1 …