Targeting heat shock proteins in cancer: a promising therapeutic approach
Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …
folding and maturation of a variety of “client” proteins protecting them from degradation …
HSP70 multi-functionality in cancer
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …
Heat shock proteins promote cancer: it's a protection racket
SK Calderwood, J Gong - Trends in biochemical sciences, 2016 - cell.com
Heat shock proteins (HSP) are expressed at high levels in cancer and form a fostering
environment that is essential for tumor development. Here, we review the recent data in this …
environment that is essential for tumor development. Here, we review the recent data in this …
[HTML][HTML] The human HSP70 family of chaperones: where do we stand?
J Radons - Cell Stress and Chaperones, 2016 - Elsevier
The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …
the most ubiquitous classes of chaperones and is highly conserved in all organisms …
The role of heat shock proteins in cancer
Heat shock proteins (HSPs) are an evolutionary family of proteins that act as molecular
chaperones. According to their size they have been classified into the following families; …
chaperones. According to their size they have been classified into the following families; …
The chaperone-assisted selective autophagy complex dynamics and dysfunctions
B Tedesco, L Vendredy, V Timmerman, A Poletti - Autophagy, 2023 - Taylor & Francis
Each protein must be synthesized with the correct amino acid sequence, folded into its
native structure, and transported to a relevant subcellular location and protein complex. If …
native structure, and transported to a relevant subcellular location and protein complex. If …
The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response
BJ Lang, ME Guerrero, TL Prince, Y Okusha… - Archives of …, 2021 - Springer
Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …
Heat shock proteins regulatory role in neurodevelopment
DJ Miller, PE Fort - Frontiers in neuroscience, 2018 - frontiersin.org
Heat shock proteins (Hsps) are a large family of molecular chaperones that are well-known
for their roles in protein maturation, re-folding and degradation. While some Hsps are …
for their roles in protein maturation, re-folding and degradation. While some Hsps are …
Breaking BAG: the co-chaperone BAG3 in health and disease
C Behl - Trends in pharmacological sciences, 2016 - cell.com
Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins
that currently consists of six members (BAG1–6) all sharing the BAG protein domain from …
that currently consists of six members (BAG1–6) all sharing the BAG protein domain from …
The role of the multifunctional BAG3 protein in cellular protein quality control and in disease
E Stürner, C Behl - Frontiers in molecular neuroscience, 2017 - frontiersin.org
In neurons, but also in all other cells the complex proteostasis network is monitored and
tightly regulated by the cellular protein quality control (PQC) system. Beyond folding of newly …
tightly regulated by the cellular protein quality control (PQC) system. Beyond folding of newly …