DNA methylation is an epigenetic mechanism that is related to mammalian cellular
differentiation, gene expression regulation, and disease. In several studies, DNA …

Recent developments have revolutionized the study of biomolecules. Among them are
molecular markers, amplification and sequencing of nucleic acids. The latter is classified into …

Since the onset of the COVID-19 pandemic, increasing cases with variable outcomes
continue globally because of variants and despite vaccines and therapies. There is a need …

Deciphering cell-type heterogeneity is crucial for systematically understanding tissue
homeostasis and its dysregulation in diseases. Computational deconvolution is an efficient …

Recent genome-wide association studies corroborate classical research on developmental
programming indicating that obesity is primarily a neurodevelopmental disease strongly …

Detection of cellular changes in tissue biopsies has been the basis for cancer diagnostics.
However, tissue biopsies are invasive and limited by inaccuracies due to sampling …

Epigenetics studies inheritable and reversible modifications of DNA that allow cells to
control gene expression throughout their development and in response to environmental …

Abstract Background We recently identified~ 10,000 correlated regions of systemic
interindividual epigenetic variation (CoRSIVs) in the human genome. These methylation …

DNA methylation analysis by sequencing is becoming increasingly popular, yielding
methylomes at single-base pair and single-molecule resolution. It has tremendous potential …

In this review, we provide a comprehensive overview of the different computational tools that
have been published for the deconvolution of bulk DNA methylation (DNAm) data. Here …