Dermal and transdermal delivery of pharmaceutically relevant macromolecules
S Münch, J Wohlrab, RHH Neubert - European journal of Pharmaceutics …, 2017 - Elsevier
The skin offers an attractive way for dermal and transdermal drug delivery that is why the
drug still needs certain qualities to transcend the outermost layer of the skin, the stratum …
drug still needs certain qualities to transcend the outermost layer of the skin, the stratum …
Perspectives on transdermal electroporation
K Ita - Pharmaceutics, 2016 - mdpi.com
Transdermal drug delivery offers several advantages, including avoidance of erratic
absorption, absence of gastric irritation, painlessness, noninvasiveness, as well as …
absorption, absence of gastric irritation, painlessness, noninvasiveness, as well as …
[HTML][HTML] Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs
T Liu, M Chen, J Fu, Y Sun, C Lu, G Quan, X Pan… - … Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides have become a significant therapeutic modality for various diseases
because of their high potency and specificity. However, the inherent properties of these …
because of their high potency and specificity. However, the inherent properties of these …
Mechanistic view of skin electroporation–models and dosimetry for successful applications: an expert review
J Dermol-Černe, E Pirc, D Miklavčič - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction Skin electroporation is a promising treatment for transdermal drug delivery,
gene electrotransfer, skin rejuvenation, electrochemotherapy, and wound disinfection …
gene electrotransfer, skin rejuvenation, electrochemotherapy, and wound disinfection …
Recent advances in skin penetration enhancers for transdermal gene and drug delivery
There is a growing interest in transdermal delivery systems because of their noninvasive,
targeted, and on-demand delivery of gene and drugs. However, efficient penetration of …
targeted, and on-demand delivery of gene and drugs. However, efficient penetration of …
Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes
Abstract Aims 3′, 5′-Cyclic adenosine monophosphate (cAMP) signals in the heart are
often confined to concentration microdomains shaped by cAMP diffusion and enzymatic …
often confined to concentration microdomains shaped by cAMP diffusion and enzymatic …
Recent advances in the transdermal delivery of protein therapeutics with a combinatorial system of chemical adjuvants and physical penetration enhancements
Since the development of protein‐based therapeutics, research has been underway to
deliver protein therapeutics into the systemic circulation and target sites have been actively …
deliver protein therapeutics into the systemic circulation and target sites have been actively …
An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management
Fentanyl transdermal therapy is a suitable treatment for moderate-to-severe cancer-related
pain. The inter-individual variability of the patients leads to different therapy responses. This …
pain. The inter-individual variability of the patients leads to different therapy responses. This …
Nanosecond range electric pulse application as a non-viral gene delivery method: Proof of concept
Current electrotransfection protocols are well-established for decades and, as a rule, employ
long micro-millisecond range electric field pulses to facilitate DNA transfer while application …
long micro-millisecond range electric field pulses to facilitate DNA transfer while application …
Electroporation of skin stratum corneum lipid bilayer and molecular mechanism of drug transport: A molecular dynamics study
The electroporation technique has been used significantly to increase drug permeation
through the skin. This technique relies on the application of short-timed (microseconds to …
through the skin. This technique relies on the application of short-timed (microseconds to …