Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Impact of hypertension on cognitive function: a scientific statement from the American Heart Association

C Iadecola, K Yaffe, J Biller, LC Bratzke, FM Faraci… - …, 2016 - Am Heart Assoc
Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Defining optimal brain health in adults: a presidential advisory from the American Heart Association/American Stroke Association

PB Gorelick, KL Furie, C Iadecola, EE Smith, SP Waddy… - Stroke, 2017 - Am Heart Assoc
Cognitive function is an important component of aging and predicts quality of life, functional
independence, and risk of institutionalization. Advances in our understanding of the role of …

Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of …

BV Zlokovic, RF Gottesman, KE Bernstein… - Alzheimer's & …, 2020 - Wiley Online Library
Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

Defining the relationship between hypertension, cognitive decline, and dementia: a review

KA Walker, MC Power, RF Gottesman - Current hypertension reports, 2017 - Springer
Hypertension is a highly prevalent condition which has been established as a risk factor for
cardiovascular and cerebrovascular disease. Although the understanding of the relationship …

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

C Reitz, R Mayeux - Biochemical pharmacology, 2014 - Elsevier
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

The lifespan human connectome project in aging: an overview

SY Bookheimer, DH Salat, M Terpstra, BM Ances… - Neuroimage, 2019 - Elsevier
Abstract The original Human Connectome Project yielded a rich data set on structural and
functional connectivity in a large sample of healthy young adults using improved methods of …

Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke …

PB Gorelick, A Scuteri, SE Black, C DeCarli… - stroke, 2011 - Am Heart Assoc
Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study

RF Gottesman, ALC Schneider, M Albert… - JAMA …, 2014 - jamanetwork.com
Importance Hypertension is a treatable potential cause of cognitive decline and dementia,
but its greatest influence on cognition may occur in middle age. Objective To evaluate the …

Epidemiology of Alzheimer disease

R Mayeux, Y Stern - Cold Spring Harbor …, 2012 - perspectivesinmedicine.cshlp.org
The global prevalence of dementia has been estimated to be as high as 24 million, and is
predicted to double every 20 years until at least 2040. As the population worldwide …