Despite the exponential growth of approved antiepileptic drugs (AEDs) over the past 25
years, epilepsy remains uncontrolled in approximately a third of patients. This article …

Synopsis Vigabatrin was specifically designed to enhance γ-aminobutyric acid (GABA)
function in the CNS. By increasing brain concentrations of this inhibitory neurotransmitter the …

Vigabatrin (VGB) is a structural analogue of γ‐aminobutyric acid (GABA) that irreversibly
inhibits GABA‐transaminase (GABA‐T), increasing brain levels of GABA. VGB is under …

Background Vigabatrin is a newly licensed drug for use in patients with epilepsy. We
investigated whether this drug was comparable to standard first-line monotherapy in efficacy …

The drug therapy of epilepsy evolved enormously in this 50 year period. Advances in
therapeutics included the incorporation of pharmacokinetics into clinical practice, enormous …

Most children with new-onset epilepsy achieve seizure freedom with appropriate
antiepileptic drugs (AEDs). However, nearly 20% will continue to have seizures despite …

Ben‐Menachem E. Mechanism of action of vigabatrin: correcting misperceptions. Acta
Neurol Scand: 2011: 124 (Suppl. 192): 5–15.© 2011 John Wiley & Sons A/S. Discovered …

The aim of this review was to examine the clinical effectiveness, tolerability and cost-
effectiveness of newer drugs for epilepsy in adults. For the purposes of this review newer …

When the brain concentration of the inhibitory neurotransmitter γ-aminobutyric acid (GABA)
diminishes below a threshold level, the excess neuronal excitation can lead to convulsions …

During the Past decade, nine new antiepileptic drugs (AEDs) namely, Felbamate,
Gabapentin, Levetiracetam, Lamotrigine, Oxcarbazepine, Tiagabine, Topiramate, Vigabatrin …