Reactive oxygen species in metabolic and inflammatory signaling
Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …
and pathophysiological signal transduction. Enzymes and subcellular compartments that …
Oxidative stress in atherosclerosis
Abstract Purpose of Review Atherosclerosis is now considered a chronic inflammatory
disease. Oxidative stress induced by generation of excess reactive oxygen species has …
disease. Oxidative stress induced by generation of excess reactive oxygen species has …
Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular …
H Yanai, H Adachi, M Hakoshima… - International journal of …, 2021 - mdpi.com
Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the
end product of an exogenous purine from food and endogenously from damaged, dying …
end product of an exogenous purine from food and endogenously from damaged, dying …
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …
[HTML][HTML] Regulation of uric acid metabolism and excretion
Purines perform many important functions in the cell, being the formation of the monomeric
precursors of nucleic acids DNA and RNA the most relevant one. Purines which also …
precursors of nucleic acids DNA and RNA the most relevant one. Purines which also …
Sources of vascular nitric oxide and reactive oxygen species and their regulation
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems
JM Lü, PH Lin, Q Yao, C Chen - Journal of cellular and …, 2010 - Wiley Online Library
Introduction• Free radical scavenging‐Scavenging superoxide and other ROS‐Scavenging
hydroxyl radical and other ROS‐Stable radical scavenging• Metal ion (Fe2+, Fe3+, Cu2+ …
hydroxyl radical and other ROS‐Stable radical scavenging• Metal ion (Fe2+, Fe3+, Cu2+ …
Impact of oxidative stress on the heart and vasculature: part 2 of a 3-part series
Vascular disease and heart failure impart an enormous burden in terms of global morbidity
and mortality. Although there are many different causes of cardiac and vascular disease …
and mortality. Although there are many different causes of cardiac and vascular disease …
Vascular oxidative stress, nitric oxide and atherosclerosis
H Li, S Horke, U Förstermann - Atherosclerosis, 2014 - Elsevier
In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme
systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide …
systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide …
Reactive oxygen species in cardiovascular disease
K Sugamura, JF Keaney Jr - Free radical biology and medicine, 2011 - Elsevier
Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …