Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in develo** countries. Usually, it is controlled by a vigorous …

Trained immunity—basic concepts and contributions to immunopathology

J Ochando, WJM Mulder, JC Madsen… - Nature Reviews …, 2023 - nature.com
Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …

A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development

K Fowler, J Mucha, M Neumann, W Lewandowski… - BMC Public Health, 2022 - Springer
Background Cytomegalovirus (CMV) is a common pathogen that affects individuals of all
ages and establishes lifelong latency. Although CMV is typically asymptomatic in healthy …

Dissecting human population variation in single-cell responses to SARS-CoV-2

Y Aquino, A Bisiaux, Z Li, M O'Neill, J Mendoza-Revilla… - Nature, 2023 - nature.com
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …

[HTML][HTML] Alzheimer's disease as a viral disease: Revisiting the infectious hypothesis

F Bruno, P Abondio, R Bruno, L Ceraudo… - Ageing research …, 2023 - Elsevier
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …

Programming cytomegalovirus as an HIV vaccine

LJ Picker, JD Lifson, M Gale, SG Hansen, K Früh - Trends in immunology, 2023 - cell.com
The initial development of cytomegalovirus (CMV) as a vaccine vector for HIV/simian
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …

Human cytomegalovirus latency and reactivation in allogeneic hematopoietic stem cell transplant recipients

L Stern, B Withers, S Avdic, D Gottlieb… - Frontiers in …, 2019 - frontiersin.org
Human cytomegalovirus (HCMV) reactivation is a major infectious cause of morbidity and
mortality after allogeneic hematopoietic stem cell transplantation (HSCT). HCMV is a …

Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection

EC Semmes, IG Miller, CE Wimberly… - The Journal of …, 2022 - Am Soc Clin Investig
Human cytomegalovirus (HCMV) is the most common congenital infection and a leading
cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide …

Genomic and geographical structure of human cytomegalovirus

OJ Charles, C Venturini, S Gantt… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (CMV) has infected humans since the origin of our species and
currently infects most of the world's population. Variability between CMV genomes is the …

The healthy human virome: from virus–host symbiosis to disease

EV Koonin, VV Dolja, M Krupovic - Current opinion in virology, 2021 - Elsevier
Viruses are ubiquitous, essential components of any ecosystem, and of multicellular
organism holobionts. Numerous viruses cause acute infection, killing the host or being …