Drug resistance developed towards conventional therapy is one of the important reasons for
chemotherapy failure in cancer. The various underlying mechanism for drug resistance …

Aggressive and recurrent gynecological cancers are associated with worse prognosis and a
lack of effective therapeutic response. Ovarian cancer (OC) patients are often diagnosed in …

Platinum is the backbone of systemic treatment in ovarian cancer and development of
platinum resistance is associated with poor survival. Here, we perform a comprehensive …

Ovarian cancer (OVCA) is the second most common gynecological cancer and one of the
leading causes of cancer related mortality among women. Recent studies suggest that …

Ethnopharmacological relevance Astragalus membranaceus which was originally described
in the Shennong's Classic of Materia Medica, the earliest complete Pharmacopoeia of China …

Drug resistance is arguably one of the biggest challenges facing cancer research today.
Understanding the underlying mechanisms of drug resistance in tumor progression and …

Ovarian carcinoma features pronounced clinical, histopathological, and molecular
heterogeneity. There is good reason to believe that parts of this heterogeneity can be …

Cancer cell mutations can be identified by genomic and transcriptomic techniques.
However, they are not sufficient to understand the full complexity of cancer heterogeneity …

Tumor recurrence hinders treatment of ovarian cancer. The present study aimed to identify
potential biomarkers for ovarian cancer recurrence prognosis and explore relevant …

Cancer has been described as the wound that does not heal, in large part due to fibroblast
involvement. Activation of cancer-associated fibroblasts (CAFs) contributes to critical …