In vivo bio‐safety evaluations and diagnostic/therapeutic applications of chemically designed mesoporous silica nanoparticles

Y Chen, H Chen, J Shi - Advanced Materials, 2013 - Wiley Online Library
The remarkable progress of nanotechnology and its application in biomedicine have greatly
expanded the ranges and types of biomaterials from traditional organic material‐based …

Emerging strategies of nanomaterial‐mediated tumor radiosensitization

J **e, L Gong, S Zhu, Y Yong, Z Gu… - Advanced …, 2019 - Wiley Online Library
Nano‐radiosensitization has been a hot concept for the past ten years, and the nanomaterial‐
mediated tumor radiosensitization method is mainly focused on increasing intracellular …

[HTML][HTML] Metal-based nanoenhancers for future radiotherapy: radiosensitizing and synergistic effects on tumor cells

Y Liu, P Zhang, F Li, X **, J Li, W Chen, Q Li - Theranostics, 2018 - ncbi.nlm.nih.gov
Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past
decade, there has been growing interest in using high Z (atomic number) elements …

[HTML][HTML] Nanoparticles for radiation therapy enhancement: the key parameters

P Retif, S Pinel, M Toussaint, C Frochot, R Chouikrat… - Theranostics, 2015 - ncbi.nlm.nih.gov
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It
does not establish an exhaustive list of the works in this field but rather propose constructive …

[HTML][HTML] Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer

D Kwatra, A Venugopal, S Anant - Translational Cancer Research, 2013 - tcr.amegroups.org
Acquired radiation resistance is one of the major causes of radio therapy failure and
subsequent tumor relapse. Multiple approaches have been utilized to limit the radiation …

Engineered gadolinium-doped carbon dots for magnetic resonance imaging-guided radiotherapy of tumors

F Du, L Zhang, L Zhang, M Zhang, A Gong, Y Tan… - Biomaterials, 2017 - Elsevier
The effectiveness of radiotherapy can decrease due to inaccurate positioning of machinery
and inherent radioresistance of tumors. To address this issue, we present a novel …

Engineered nanomaterial uptake and tissue distribution: from cell to organism

H Kettiger, A Schipanski, P Wick… - International journal of …, 2013 - Taylor & Francis
Improved understanding of interactions between nanoparticles and biological systems is
needed to develop safety standards and to design new generations of nanomaterials. This …

AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

H Sun, H Cai, C Xu, H Zhai, F Lux, Y **e, L Feng… - Journal of …, 2022 - Springer
In the frame of radiotherapy treatment of cancer, radioresistance remains a major issue that
still needs solutions to be overcome. To effectively improve the radiosensitivity of tumors and …

[HTML][HTML] Gadolinium-based nanoparticles and radiation therapy for multiple brain melanoma metastases: proof of concept before phase I trial

S Kotb, A Detappe, F Lux, F Appaix, EL Barbier… - Theranostics, 2016 - ncbi.nlm.nih.gov
Nanoparticles containing high-Z elements are known to boost the efficacy of radiation
therapy. Gadolinium (Gd) is particularly attractive because this element is also a positive …

Long-Term in Vivo Clearance of Gadolinium-Based AGuIX Nanoparticles and Their Biocompatibility after Systemic Injection

L Sancey, S Kotb, C Truillet, F Appaix, A Marais… - ACS …, 2015 - ACS Publications
We previously reported the synthesis of gadolinium-based nanoparticles (NPs) denoted
AGuIX (activation and guiding of irradiation by X-ray) NPs and demonstrated their potential …