Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial–mesenchymal transition

W ** - Cells, 2020 - mdpi.com
The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Ca2+ fluxes and cancer

S Marchi, C Giorgi, L Galluzzi, P Pinton - Molecular cell, 2020 - cell.com
Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer–A comprehensive review from chemotherapy to immunotherapy

PJ Kaboli, F Salimian, S Aghapour, S **ang… - Pharmacological …, 2020 - Elsevier
Breast cancer is the most frequently occurring cancer in women. Chemotherapy in
combination with immunotherapy has been used to treat breast cancer. Atezolizumab …

[HTML][HTML] Calcium signaling and the therapeutic targeting of cancer cells

AHL Bong, GR Monteith - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
The calcium signal is implicated in a variety of processes important in tumor progression (eg
proliferation and invasiveness). The calcium signal has also been shown to be important in …

Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis

S O'Grady, MP Morgan - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
The implementation of mammographic screening programmes in many countries has been
linked to a marked increase in early detection and improved prognosis for breast cancer …

Calcium signaling in cancer progression and therapy

L Wu, W Lian, L Zhao - The FEBS journal, 2021 - Wiley Online Library
The old Greek aphorism 'Panta Rhei'('everything flows') is true for all living things in general.
As a dynamic process, calcium signaling plays fundamental roles in cellular activities under …

Mechanosensitive ion channels push cancer progression

Z Pethő, K Najder, E Bulk, A Schwab - Cell Calcium, 2019 - Elsevier
In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …

Red (635 nm), near-infrared (808 nm) and violet-blue (405 nm) photobiomodulation potentiality on human osteoblasts and mesenchymal stromal cells: a …

A Tani, F Chellini, M Giannelli, D Nosi… - International journal of …, 2018 - mdpi.com
Photobiomodulation (PBM) has been used for bone regenerative purposes in different fields
of medicine and dentistry, but contradictory results demand a skeptical look for its potential …

Ion channels in the regulation of autophagy

A Kondratskyi, K Kondratska, R Skryma, DJ Klionsky… - Autophagy, 2018 - Taylor & Francis
Autophagy is a cellular process in which the cell degrades and recycles its own constituents.
Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is …

The role of TRPC1 in modulating cancer progression

OM Elzamzamy, R Penner, LA Hazlehurst - Cells, 2020 - mdpi.com
Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora
of physiological and pathological processes, including the progression of cancer. Several …