Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …

Cells receive extracellular stimuli in various ways: in the form of soluble molecules (growth
factors, cytokines and hormones) that interact with cell-surface receptors; from adhesive …

This review summarizes what is known about the biochemical and biophysical mechanisms
that initiate the assembly of actin filaments in cells. Assembly and disassembly of these …

Actin is a key structural protein that makes up the cytoskeleton of cells, and plays a role in
functions such as division, migration, and vesicle trafficking. It comprises six different cell …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Dynamic rearrangement of the actin cytoskeleton drives a myriad of processes in eukaryotic
cells, such as cell migration and vesicle trafficking, and its dysregulation is deeply …

The Arp2/3 complex regulates endocytosis, sorting, and trafficking, yet the Arp2/3-stimulating
factors orchestrating these distinct events remain ill defined. WASH (Wiskott-Aldrich …