Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

In clinical therapy of evolving acute myocardial infarction, coronary reperfusion has proven
to be the only way to limit infarct size, provided it occurs soon enough after coronary artery …

As of yet, only a few strategies to prevent myocardial reperfusion injury have been tested
clinically. In the first minutes of reperfusion, the myocardium can be damaged by contracture …

First, we present a summary of the evidence for our model of the molecular mechanism of
the permeability transition (MPT). Our proposal is that the MPT occurs as a result of the …

During the past decade, the understanding has grown that control of the conditions of
reperfusion is critical for salvaging ischemic–reperfused myocardium. The first few minutes …

The Na+-H+ exchange (NHE) is a major mechanism by which the heart adapts to
intracellular acidosis during ischemia and recovers from the acidosis after reperfusion …