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Bridging live-cell imaging and next-generation cancer treatment
By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …
provide a deeper understanding of the cellular and signalling events that determine cancer …
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response
Modeling immuno-oncology by using patient-derived material and immune cell co-cultures
can advance our understanding of immune cell tumor targeting in a patient-specific manner …
can advance our understanding of immune cell tumor targeting in a patient-specific manner …
Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling
Chimeric antigen receptor (CAR) T cells used for the treatment of B cell malignancies can
identify T cell subsets with superior clinical activity. Here, using infusion products of …
identify T cell subsets with superior clinical activity. Here, using infusion products of …
Metformin treatment rescues CD8+ T-cell response to immune checkpoint inhibitor therapy in mice with NAFLD
Background & Aims Non-alcoholic steatohepatitis (NASH) represents the fastest growing
underlying cause of hepatocellular carcinoma (HCC) and has been shown to impact …
underlying cause of hepatocellular carcinoma (HCC) and has been shown to impact …
[HTML][HTML] Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer
Tissue-resident macrophages adapt to local signals within tissues to acquire specific
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …
ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors
Adoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is
becoming a promising treatment option for hematological malignancies. However, T cell …
becoming a promising treatment option for hematological malignancies. However, T cell …
Chronic antigen in solid tumors drives a distinct program of T cell residence
Analyses of healthy tissue reveal signatures that identify resident memory CD8+ T cells
(TRM), which survey tissues without recirculating. The density of TRM phenotype cells within …
(TRM), which survey tissues without recirculating. The density of TRM phenotype cells within …
Motion blur microscopy: in vitro imaging of cell adhesion dynamics in whole blood flow
Imaging and characterizing the dynamics of cellular adhesion in blood samples is of
fundamental importance in understanding biological function. In vitro microscopy methods …
fundamental importance in understanding biological function. In vitro microscopy methods …
Enhancing T cell chemotaxis and infiltration in glioblastoma
Simple Summary Immunotherapy in glioblastoma has so far failed to yield a survival benefit.
This failure can be attributed to a paucity of immune cells at the tumor site which can be …
This failure can be attributed to a paucity of immune cells at the tumor site which can be …
Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function
C Tian, Y Wang, M Su, Y Huang, Y Zhang, J Dou… - Nature …, 2024 - nature.com
Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of
tumors. Most mechanistic studies focus on their static functional status before or after …
tumors. Most mechanistic studies focus on their static functional status before or after …