The miRNA–target interactions: an underestimated intricacy

C Diener, A Keller, E Meese - Nucleic Acids Research, 2024 - academic.oup.com
MicroRNAs (miRNAs) play indispensable roles in posttranscriptional gene regulation. Their
cellular regulatory impact is determined not solely by their sheer number, which likely …

Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

[HTML][HTML] MicroRNA therapeutics in cancer: current advances and challenges

S Reda El Sayed, J Cristante, L Guyon, J Denis… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …

[HTML][HTML] Circulating miRNAs as a tool for early diagnosis of endometrial cancer—implications for the fertility-sparing process: clinical, biological, and legal aspects

R Piergentili, G Gullo, G Basile, C Gulia… - International Journal of …, 2023 - mdpi.com
This review article explores the possibility of develo** an integrated approach to the
management of the different needs of endometrial cancer (EC) patients seeking to become …

MicroRNAs in pancreatic cancer: advances in biomarker discovery and therapeutic implications

R Madadjim, T An, J Cui - International Journal of Molecular Sciences, 2024 - mdpi.com
Pancreatic cancer remains a formidable malignancy characterized by high mortality rates,
primarily attributable to late-stage diagnosis and a dearth of effective therapeutic …

Role of CD44 in breast cancer

N Al-Othman, A Alhendi, M Ihbaisha… - Breast …, 2020 - journals.sagepub.com
Breast cancer (BC) is among the most prevalent type of malignancy affecting females
worldwide. BC is classified into different types according to the status of the expression of …

Discerning the prospects of miRNAs as a multi-target therapeutic and diagnostic for alzheimer's disease

D Bhatnagar, S Ladhe, D Kumar - Molecular Neurobiology, 2023 - Springer
Although over the last few decades, numerous attempts have been made to halt Alzheimer's
disease (AD) progression and mitigate its symptoms, only a few have been proven …

MicroRNA cues from nature: a roadmap to decipher and combat challenges in human health and disease?

G Singh, KB Storey - Cells, 2021 - mdpi.com
MicroRNAs are small non-coding RNA (18–24 nt long) that fine-tune gene expression at the
post-transcriptional level. With the advent of “multi-omics” analysis and sequencing …

Sample‐to‐answer salivary miRNA testing: New frontiers in point‐of‐care diagnostic technologies

Z Zhang, T Liu, M Dong, MA Ahamed… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Abstract MicroRNA (miRNA), crucial non‐coding RNAs, have emerged as key biomarkers in
molecular diagnostics, prognosis, and personalized medicine due to their significant role in …

Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

LM Ruiz‐Manriquez, C Estrada‐Meza… - Phytotherapy …, 2022 - Wiley Online Library
MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two main categories of
noncoding RNAs (ncRNAs) that can influence essential biological functions in various ways …