The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle
progression during mitosis with the state of chromosome attachment to the mitotic spindle …

The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

All eukaryotic cells prepare for cell division by forming a “mitotic spindle”—a bipolar machine
made from microtubules (MTs) and many associated proteins. This device organizes the …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …

Cell division is enacted by a microtubule-based, self-assembling macromolecular machine
known as the mitotic spindle. In 1986, Kirschner and Mitchison proposed that by undergoing …

Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …