Bacterial cyclophane-containing RiPPs from radical SAM enzymes
Covering: 2016 to 2023 Ribosomally synthesized and posttranslationally modified peptides
(RiPPs) continue to be a rich source of chemically diverse and bioactive peptide natural …
(RiPPs) continue to be a rich source of chemically diverse and bioactive peptide natural …
Bacterial Cytochrome P450 Catalyzed Post‐translational Macrocyclization of Ribosomal Peptides
Ribosomally synthesized and post‐translationally modified peptides (RiPPs) are a
fascinating group of natural products that exhibit diverse structural features and bioactivities …
fascinating group of natural products that exhibit diverse structural features and bioactivities …
Substrate-controlled catalysis in the ether cross-link-forming radical SAM enzymes
Darobactin is a heptapeptide antibiotic featuring an ether cross-link and a C–C cross-link,
and both cross-links are installed by a radical S-adenosylmethionine (rSAM) enzyme DarE …
and both cross-links are installed by a radical S-adenosylmethionine (rSAM) enzyme DarE …
Discovery and engineering of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products
Ribosomally synthesized and post-translationally modified peptides (RiPPs) represent a
diverse superfamily of natural products with immense potential for drug development. This …
diverse superfamily of natural products with immense potential for drug development. This …
Biosynthesis of macrocyclic peptides with C-terminal β-amino-α-keto acid groups by three different metalloenzymes
DT Nguyen, L Zhu, DL Gray, TJ Woods… - ACS Central …, 2024 - ACS Publications
Advances in genome sequencing and bioinformatics methods have identified a myriad of
biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining …
biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining …
Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical S-Adenosylmethionine Enzymes
The radical S-adenosylmethionine (rSAM) superfamily has become a wellspring for
discovering new enzyme chemistry, especially regarding ribosomally synthesized and post …
discovering new enzyme chemistry, especially regarding ribosomally synthesized and post …
Bacterial Cytochrome P450 Catalyzed Macrocyclization of Ribosomal Peptides
Macrocyclization is a vital process in the biosynthesis of ribosomally synthesized and post-
translationally modified peptides (RiPPs), significantly enhancing their structural diversity …
translationally modified peptides (RiPPs), significantly enhancing their structural diversity …
Rule-based omics mining reveals antimicrobial macrocyclic peptides against drug-resistant clinical isolates
Antimicrobial resistance remains a significant global threat, driving up mortality rates
worldwide. Ribosomally synthesized and post-translationally modified peptides have …
worldwide. Ribosomally synthesized and post-translationally modified peptides have …
Genome Mining for New Enzyme Chemistry
A revolution in the field of biocatalysis has enabled scalable access to compounds of high
societal values using enzymes. The construction of biocatalytic routes relies on the reservoir …
societal values using enzymes. The construction of biocatalytic routes relies on the reservoir …
Aromatic side-chain crosslinking in RiPP biosynthesis
Peptide cyclization is a defining feature of many bioactive molecules, particularly in the
ribosomally synthesized and post-translationally modified peptide (RiPP) family of natural …
ribosomally synthesized and post-translationally modified peptide (RiPP) family of natural …