Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and
obesity epidemic. Diabetes and fluctuations of blood sugar are related to multiple micro-and …

Normally, smooth muscle cells (SMCs) are localized in the tunica media of the vasculature,
where they take responsibility for vascular contraction and extracellular matrix (ECM) …

Diabetes mellitus (DM) is a chronic disease that affects nowadays millions of people
worldwide. In adults, type 2 diabetes mellitus (T2DM) accounts for the majority of all …

Prolonged perturbation of the endoplasmic reticulum (ER) leads to ER stress and unfolded
protein response (UPR) and contributes to the pathogenesis of various chronic disorders …

The endoplasmic reticulum (ER) is a multifunctional intracellular organelle, a component of
the cellular reticular network that allows cells to adjust to a wide variety of conditions. The …

In different pathological states that cause endoplasmic reticulum (ER) calcium depletion,
altered glycosylation, nutrient deprivation, oxidative stress, DNA damage or energy …

COL4A3/A4/A5 mutations have been identified as critical causes of Alport syndrome and
other genetic chronic kidney diseases. However, the underlying pathogenesis remains …

Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic
reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the …

Patients with diabetes mellitus often develop corneal complications and delayed wound
healing. How diabetes might alter acute inflammatory responses to tissue injury, leading to …

Background Endothelial dysfunction is a crucial early phenomenon in vascular diseases
linked to diabetes mellitus and associated to enhanced oxidative stress. There is increasing …