Hepatitis A is a vaccine-preventable infection caused by the hepatitis A virus (HAV). Over
150 million new infections of hepatitis A occur annually. HAV causes an acute inflammatory …

Infectious hepatitis type A and type E are caused by phylogenetically distinct single-
stranded, positive-sense RNA viruses that were once considered to be non-enveloped …

Background and purpose Despite decades of improved sanitation and hygiene measures
and vaccine introduction, hepatitis A has been spread through numerous outbreaks globally …

Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

Humans harbour a large quantity of microbes in the intestinal tract and have evolved
symbiotic relationships with many of them. However, several specific bacterial pathobionts …

Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and
increases the severity with age. Although in most patients the infection resolves completely …

A critical step in the life cycle of a virus is spread to a new target cell, which generally
involves the release of new viral particles from the infected cell which can then initiate …

Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of
hospitalizations and hundreds of deaths within the United States in recent years. There is no …

Virus-induced changes in host lipid metabolism are an important but poorly understood
aspect of viral pathogenesis. By combining nontargeted lipidomics analyses of infected cells …

Hepatitis A virus (HAV) is a positive-sense RNA virus causing acute inflammation of the liver.
Here, using a genome-scale CRISPR screen, we provide a comprehensive picture of the …