Recent advances with liposomes as pharmaceutical carriers

VP Torchilin - Nature reviews Drug discovery, 2005 - nature.com
Liposomes—microscopic phospholipid bubbles with a bilayered membrane structure—have
received a lot of attention during the past 30 years as pharmaceutical carriers of great …

Multifunctional nanocarriers

VP Torchilin - Advanced drug delivery reviews, 2006 - Elsevier
Currently used pharmaceutical nanocarriers, such as liposomes, micelles, nanoemulsions,
polymeric nanoparticles and many others demonstrate a broad variety of useful properties …

Targeted pharmaceutical nanocarriers for cancer therapy and imaging

VP Torchilin - The AAPS journal, 2007 - Springer
The use of various pharmaceutical nanocarriers has become one of the most important
areas of nanomedicine. Ideally, such carriers should be specifically delivered (targeted) to …

Passive and active drug targeting: drug delivery to tumors as an example

VP Torchilin - Drug delivery, 2010 - Springer
The paradigm of using nanoparticulate pharmaceutical carriers has been well established
over the past decade, both in pharmaceutical research and in the clinical setting. Drug …

Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells

M Thomas, AM Klibanov - Proceedings of the National …, 2003 - National Acad Sciences
Branched polyethylenimine (PEI) chains with an average molecular mass of 2 kDa (PEI2)
have been covalently attached to gold nanoparticles (GNPs), and the potency of the …

Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention

SK Sahoo, V Labhasetwar - Molecular pharmaceutics, 2005 - ACS Publications
We studied the molecular mechanism of greater efficacy of paclitaxel-loaded nanoparticles
(Tx-NPs) following conjugation to transferrin (Tf) ligand in breast cancer cell line. NPs were …

Efficacy of transferrin‐conjugated paclitaxel‐loaded nanoparticles in a murine model of prostate cancer

SK Sahoo, W Ma, V Labhasetwar - International journal of …, 2004 - Wiley Online Library
Chemotherapy remains the preferred choice of treatment for prostate cancer but modest
drug response and significant toxicity by conventional methods of administration limit their …

pH‐Sensitive liposomes‐principle and application in cancer therapy

H Karanth, RSR Murthy - Journal of pharmacy and …, 2007 - Wiley Online Library
The purpose of this review is to provide an insight into the different aspects of pH‐sensitive
liposomes. The review consists of 6 parts: the first introduces different types of medications …

Antibody-modified liposomes for cancer chemotherapy

V Torchilin - Expert opinion on drug delivery, 2008 - Taylor & Francis
Background: Liposomes, phospholipids, nanosized bubbles with a bilayered membrane
structure, have drawn a lot of interest as pharmaceutical carriers for drugs and genes. In …

Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems

S Hama, H Akita, R Ito, H Mizuguchi, T Hayakawa… - Molecular Therapy, 2006 - cell.com
To develop nonviral gene vectors that are sufficient for clinical application, it is necessary to
understand why and to what extent nonviral vectors are inferior to viral vectors, which in …