Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Neutrophils are the most abundant innate immune cell with critical anti-microbial functions.
Since the discovery of granulocytes at the end of the nineteenth century, the cells have been …

The accumulation of circulating low‐density neutrophils (LDN) has been described in cancer
patients and associated with tumor‐supportive properties, as opposed to the high‐density …

The term “vasculitis” refers to a group of rare immune‐mediated diseases characterized by
the dysregulated immune system attacking blood vessels located in any organ of the body …

Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic
changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As …

Multiparameter flow cytometry (MFC) is one of the essential ancillary methods in bone
marrow (BM) investigation of patients with cytopenia and suspected myelodysplastic …

A body of evidence has re‐energized the interest on the role neutrophils in inflammatory and
autoimmune conditions. For decades, neutrophils have been considered a homogenous …

COVID-19 can cause acute respiratory distress syndrome, leading to death in many
individuals. Evidence of a deleterious role of the innate immune system is accumulating, but …

Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a serious
autoimmune disease that is characterized by vascular necrosis. The pathogenesis of AAV …