Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types,
including neurons, glial cells and blood vessels, and are involved or implicated in brain …

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Alzheimer's disease (AD) and treatment of the brain in aging require the development of
new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large …

Neuronal synapse formation and remodeling are essential to central nervous system (CNS)
development and are dysfunctional in neurodevelopmental diseases. Innate immune …

Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic
amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous …

Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's
disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic …

Astrocytes exist throughout the nervous system and are proposed to affect neural circuits
and behavior. However, studying astrocytes has proven difficult because of the lack of tools …

Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …

The high turnover and regenerative capacity of the adult intestine relies on resident stem
cells located at the bottom of the crypt. The enteric nervous system consists of an abundant …

Neuroinflammation is one of the most striking hallmarks of amyotrophic lateral sclerosis
(ALS). Nuclear factor-kappa B (NF-κB), a master regulator of inflammation, is upregulated in …