Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses
since 2014. The method provides high resolution capable of separating carbohydrates by …

Glycosylation is one of the most significant and abundant posttranslational modifications in
mammalian cells. It mediates a wide range of biofunctions, including cell adhesion, cell …

Reversed-phase chromatography is a method that is often used for glycan separation. For
this, glycans are often derivatized with a hydrophobic tag to achieve retention on …

Porous graphitised carbon-liquid chromatography (PGC-LC) has been proven to be a
powerful technique for the analysis and characterisation of complex mixtures of isomeric and …

Glycosylation can be a critical quality attribute in biologic manufacturing. In particular, it has
implications on the half‐life, immunogenicity, and pharmacokinetics of therapeutic …

Immunoglobulin G (IgG) crystallizable fragment (Fc) glycosylation is crucial for antibody
effector functions, such as antibody-dependent cell-mediated cytotoxicity, and for their …

Abstract Changes in the glycome of human proteins and cells are associated with the
progression of multiple diseases such as Alzheimer's, diabetes mellitus, many types of …

Ageing is a complex process which implies the accumulation of molecular, cellular and
organ damage, leading to an increased vulnerability to disease. In Western societies, the …

The N-glycan of the IgG constant region (Fc) plays a central role in tuning and directing
multiple antibody functions in vivo, including antibody-dependent cellular cytotoxicity …