Non-alcoholic fatty liver disease and gut microbial dysbiosis-underlying mechanisms and gut microbiota mediated treatment strategies

M Jayachandran, S Qu - Reviews in Endocrine and Metabolic Disorders, 2023‏ - Springer
Non-alcoholic fatty liver disease (NAFLD) is by far the most prevalent form of liver disease
worldwide. It's also the leading cause of liver-related hospitalizations and deaths …

[HTML][HTML] A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation

N Randeni, M Bordiga, B Xu - International Journal of Molecular Sciences, 2024‏ - mdpi.com
The human gastrointestinal tract hosts a complex and dynamic community of
microorganisms known as the gut microbiota, which play a pivotal role in numerous …

Disruption of gut barrier integrity and host–microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus

R Forlano, L Martinez-Gili, P Takis… - Gut …, 2024‏ - Taylor & Francis
Aberration of the “gut-liver axis” contributes to the development and progression of
metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we use multi-omics …

[HTML][HTML] Tangshen formula targets the gut microbiota to treat non-alcoholic fatty liver disease in HFD mice: A 16S rRNA and non-targeted metabolomics analyses

S Wang, X Li, B Zhang, Y Li, K Chen, H Qi… - Biomedicine & …, 2024‏ - Elsevier
Background Tangshen formula (TSF) has an ameliorative effect on hepatic lipid metabolism
in non-alcoholic fatty liver disease (NAFLD), but the role played by the gut microbiota in this …

Role of gut microbiota and immune cells in metabolic-associated fatty liver disease: Clinical impact

A Alisi, G McCaughan, H Grønbæk - Hepatology international, 2024‏ - Springer
In 2020, a revised definition of fatty liver disease associated with metabolic dysfunction
(MAFLD) was proposed to replace non-alcoholic fatty liver (NAFLD). Liver steatosis and at …

Intestinal Barrier Dysfunction and Gut Microbiota in Non-Alcoholic Fatty Liver Disease: Assessment, Mechanisms, and Therapeutic Considerations

C Long, X Zhou, F **a, B Zhou - Biology, 2024‏ - mdpi.com
Simple Summary Non-alcoholic fatty liver disease (NAFLD) is a type of metabolic stress liver
injury closely related to insulin resistance (IR) and genetic susceptibility without alcohol …

Dahuang Mudan decoction repairs intestinal barrier in chronic colitic mice by regulating the function of ILC3

S Huang, X Wang, X **e, Y Su, Z Pan, Y Li… - Journal of …, 2022‏ - Elsevier
Abstract Ethnopharmacological relevance Dahuang Mudan decoction (DMD) is a classic
prescription for treating intestinal carbuncle from Zhang Zhong**g's “Essentials of the …

Long-term exposure to polystyrene microspheres and high-fat diet–induced obesity in mice: evaluating a role for microbiota dysbiosis

Z Zhai, Y Yang, S Chen, Z Wu - Environmental Health …, 2024‏ - ehp.niehs.nih.gov
Background: Microplastics (MPs) have become a global environmental problem, emerging
as contaminants with potentially alarming consequences. However, long-term exposure to …

Screening for NAFLD—current knowledge and challenges

R Forlano, G Sigon, BH Mullish, M Yee, P Manousou - Metabolites, 2023‏ - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver
function tests worldwide, with an estimated prevalence ranging between 19–46% in the …

[HTML][HTML] Gut microbiota metabolite trimethylamine N-oxide promoted NAFLD progression by exacerbating intestinal barrier disruption and intrahepatic cellular …

F Nian, Y Chen, Q **a, C Zhu, L Wu, X Lu - International …, 2024‏ - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver
disease worldwide, with the gut microbiota and its metabolites are important regulators of its …